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Hoofprint Biome

Developing probiotics and natural enzymes that improve cattle health and yield while eliminating methane

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Kathryn Polkoff

Co-Founder & CEO at Hoofprint Biome

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hoofprintbiome.com
Employees 6–20
Headquarters Durham, North Carolina, United States
Hoofprint Biome develops enzyme-based feed additives that reshape the digestive microbiome in cattle to reduce methane emissions and increase yield. The company has discovered proprietary proteins that enable microbiome modulation. Backed by mission-aligned investors such as AgriZero and SOSV, Hoofprint aims to deliver scalable, cost-effective solutions that improve animal health, farm profitability, and the environmental footprint of cattle systems worldwide.
Food & Water

Notable Achievements

  • Raised $15M Series A from SOSV, Amazon, AgriZero, Breakthrough Energy, and others.
  • Received non-dilutive NSF and USDA grants to advance technology development.
  • Built proprietary enzyme platform with global manufacturing scalability.

Currently Operating in Two Regions

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