Fleur wrote an essay on vaccines for coronaviruses (HIV) in 1992 as part of entry to Oxford University to read Biochemistry. After graduating, she started her investment banking career in London at JP Morgan.

Between 2000–2007, Fleur ran Global Trader, the "Robinhood" of Africa under the EasyEquities brand. After exiting, she attended Skoll and pivoted towards ESG and Impact investing and entrepreneurship. She seeded funds like the world-leading ESG fund Osmosis Investment Management and EdTech fund Emerge; became the CEO of Proof, an Impact Data intelligence company; joined as Chair of Pyrpose, a next-generation climate investment platform; and became an active board member of OKA, the Carbon Credit Insurance Company. Fleur and her husband Gerrit live in Cape Town, looking after four kids and King Slevin, the dog.